Change in Protein function by Mutation

Question: Talk about the Change in Protein work by Mutation? Answer: Proteins structure a wide scope of capacity that is interceded by the deposits that make up the practical site. Changes produce an emotional impact in the dynamic locales of the proteins and the coupling pockets of the receptors (Mondai Hu, 2012). Transformation is related with the change of a typical codon to a gibberish codon and accordingly influences the protein work. As indicated by Choi et al. (2012), a specific base change prompts an adjustment in the sequencing of the amino corrosive. The significant changes that produce an effect on the protein successions include: Frameshift change: Frameshift transformation causes an inclusion and cancellation of explicit nucleotides. This prompts a disturbance in the perusing outline that causes a change in the protein structure. Jabber transformation: It brings about untimely stop codon that prompts the arrangement of a nonfunctional protein item. Missense transformation: Point transformation causes an adjustment in the grouping of DNA those outcomes in single nucleotide change, which thus causes an adjustment in the sequencing of amino acids. Subsequently, the protein shaped becomes non-useful. Unbiased change: A Neutral transformation includes an amino corrosive codon that prompts the utilization of various yet artificially comparable amino acids. Quiet transformations: Silent transformations remains related with the adjustment in the amino corrosive grouping such that the amino corrosive lies in same setup with the first. References Choi, Y., Sims, G. E., Murphy, S., Miller, J. R., Chan, A. P. (2012). Foreseeing the utilitarian impact of amino corrosive replacements and indels.PloS one,7(10), e46688. Mondai, A. M., Hu, J. (2012, October). Transformation examination of infection causing proteins. InBioinformatics and Biomedicine Workshops (BIBMW), 2012 IEEE International Conference on(pp. 975-977). IEEE.

Romeo and Juliet are victims of unrelenting fate against which they cannot rebel effectively. All they can do is submit with courage and dignity. Essay Example For Students

Romeo and Juliet are casualties of persistent destiny against which they can't revolt viably. Everything they can do is submit with mental fortitude and respect. Article Who is at fault for the deplorability of Romeo and Juliet? The citation takes the perspective that destiny is at fault for the passing of Romeo and Juliet. It expresses that the result couldn't have been changed and whatever Romeo and Juliet had done, the final product would have been the equivalent. The preface of the play likewise takes this view The dreadful entry of their passing checked love Preamble. The expression passing stamped love illuminates us that their adoration is set apart with death from the earliest starting point and nothing they do will change this reality, since it is their destiny. In Elizabethan occasions the vast majority would have accepted that destiny is the primary driver of the disaster. Be that as it may, a few people may recommend that it is increasingly exact to state that it was their predetermination, which is brought about by human obligation, as opposed to their destiny, which is fixed and can't be changed, that is to be faulted. Destiny implies that the end was at that point chose for them, directly from the earliest starting point of time however fate implies that they choose their own life as they come, through the decisions they make and the through what the individuals around them do. There are numerous reasons why Romeo and Juliet arrived at such an appalling end. At last the final product was as it was a direct result of everything that happened integrating. For example, on the off chance that Tybalt had not murdered Mercutio, at that point Romeo would not have executed Tybalt and would not have been ousted. It was a grouping of heartbreaking occasions. There are numerous things it could have been; scorn, predetermination or even love. At the point when we consider love we consider something that is awesome, something that takes care of our issues and disintegrates our scorn. We can see from the play that adoration changes characters. Romeo and Juliet become urgent to hustle through everything, they cannot hold on to see one another, they need to get hitched, and they need to rest together, at the same time. Love has dominated and they cannot get enough of one another. At the point when we investigate Romeo and Juliet after they begin to look all starry eyed at we can see that their characters have changed, yet in totally different ways. Romeo gets touchy and he attempts to spread his adoration and satisfaction to others around him. I do fight I never harmed thee, in any case, love thee better than thou canst devise. 3.1.61-62 This is an unforeseen reaction from Romeo, seeing as he is a Montague and it is accepted that all Montagues abhor all Capulets. This is the reason it appears that Romeo is acting like this as a result of being infatuated. Juliet has likewise had a difference in character; she gets directing and versatile. Jog apace, you searing footed horses, What's more, get overcast night right away. Juliet, 3.2.14 This statement gives her assurance and solid self control contrasted with how she is before she began to look all starry eyed at. Before Romeo tagged along we never observed her being solid or forceful, just dutiful and affable around her mom and father. We could accuse the aftereffect of the play for some individuals for some reasons. Here I will analyze the principle guilty parties and what they did to add to the result of Romeo and Juliets love. Romeo had a major impact in the passing of Juliet and himself. His character made him be hurried and hurry into things without intuition. This made him significantly more defenseless and he imperiled himself and Juliet all the while. Right off the bat, he met Juliet was on the grounds that he went to the gathering to attempt to charm Rosaline, and when he saw Juliet, he promptly, following his rushed character, experienced passionate feelings for her and started to beguile her. On the off chance that he had not been so complying with his resentment he would not have been in such a race to make Tybalt pay for killing his companion and would not have been expelled. This shows he doesn't think about the results of his activities. Furthermore, again when he heard Juliet had passed on, he hopped on his pony and rushed off to the Capulet vault. He didn't stop to believe that some different news may show up. One World Down the Drain EssayTybalt is feisty essentially and this incites Mercutio and the different Montagues to battle him. Turn thee, Benvolio, and view thy deathpeace? I abhor the word, as I loathe heck, all Montagues, and thee. Have at thee, defeatist. 1.1.5861-63 On the off chance that he had not gone out chasing for Romeo no one would have passed on. Interestingly, none of the youngsters, from either side of the family, even have motivation to battle other than the way that their folks are foes. Mercutio is very like Tybalt from multiple points of view. The two of them appreciate battling and deriding one another and both severely dislike the others family. When Tybalt came searching for Romeo he made it very certain that he would not like to battle Mercutio and was there just for Romeo, and when Romeo showed up he excused Mercutio: Harmony be with you, sir, here comes my man. Tybalt to Mercutio 3.1.49 In any case, Mercutio demanded and it wound up that Mercutio, himself, passed on. On the off chance that Mercutio had pulled back, at that point, Romeo may never have been expelled. However, that was not in his character. In spite of the fact that we can't state that it would have been exceptional if something had been changed or if Romeo and Juliet had not passed on in such a case that this was the situation the fight would have still been occurring and the two families presumably would have dismissed their family members. The entire thing is brought about by the way that Lord Capulet and Lord Montague can't make peace and have forced their view, that the other isn't right, on their family members. The two sides of the quarrel have in any event one individual who can see that the entire battle is futile and should be sifted through. The way that Romeo and Juliet go that smidgen further to be together and take care of their families issues shows that the fight is causing only distress and that individuals have even kicked the bucket attempting to hurt an individual from the other family. I dont believe that the fault can be put on only one individual in such a case that any one thing had changed the result would have changed and we cannot pick only one thing that caused the outcome. From this we could state one of two things; either destiny is at fault or predetermination is to be faulted. Destiny generally depends on star arrangements and nothing can change what the end will be. Predetermination depends on what individuals do and the decisions they settle on, and various decisions produce various endings. What's more, as we probably am aware, on the off chance that one thing was changed about the play the result would be totally unique, we can reason that the citation is bogus and fate is to be faulted for the deplorability of Romeo and Juliet.

Price Fixing and the FTC Essay Example for Free

Value Fixing and the FTC Essay The case was discharged in the mid-2006, where the Federal Trade Commission has announced that they are testing the individuals from the Puerto Rico Association of Endodontists, Corporation or the PRAE (Commissions, 2006). This is a result of supposed value fixing coordinated efforts that they would charge on a few protection approaches and dental administrations that they offer. They have teamed up and settled on concurrences with 30 different contenders, wherein they fixed their costs to the detriment of their buyers. Along these lines, the FTC had to document a protest against this organization since it diminishes the opposition between these organizations, therefore greater expenses will be forced on the purchasers. This is an away from of the Federal Trade Commission Act, Section number 5. All together for this issue to be settled, The Puerto Rico Association of Endodontists, Corp. should cease from including in issues that advance anticompetitive lead in the coming years.  â â â â â â â â â â Through this, the Federal Trade Commission will have the option to ensure that these dental administrations and other fundamental human services issues will be given and tended to at the purchasers at costs that they could manage. Keeping a serious domain in the part of human services will open up better open doors for the individuals, alongside lower serious costs. Leaving human services alone hoarded will prompt higher evaluating and less upkeep, and would truly be a weight to the individuals, the buyers. That’s why these human services suppliers and makers ought not go about as one; they ought not team up with one another in their evaluating, in light of the fact that it removes the part of seriousness between them.  â â â â â â â â â â The protests against Puerto Rico Association of Endodontists, Corporation shows that in the year 2003, the organization has just started its haggling with their rivals, along these lines coming about to the uncommon increment in five dental plans as of now. Another expansion happened during 2004, wherein the costs likewise went up in light of their dealing. In light of these activities the ones who were endangered were the individuals; they were the ones who worried about the concern of expanded rates, since these social insurance issues is a need for everybody. The Federal Trade Commission examined that these intense changes in costs have no at all impact on the nature of administrations offered by the organization, in this manner the extra costs were not so much legitimate. It doesn’t lead to a superior nature of social insurance, in this manner, it is just a loss in the piece of the shoppers.  â â â â â â â â â â Given the circumstance, the Federal Trade Commission proposed an assent request which will be take care of the current issue. This will ideally alleviate the effect of the supposed anticompetitive activities by the Puerto Rico Association of Endodontists, Corporation and further keep it from happening once more. It would then ruin the organization to have any settlements or concurrences with different endodontists and haggle with any payor on the administrations that they offer, aside from appropriately masterminded by the association. Reference: Commissions, F. T. (2006). FTC Charges Puerto Rico Endodontists With Price Fixing.â â Retrieved August 4, 2007, from http://www.ftc.gov/opa/2006/07/prendo.shtm

The APUSH Test Dates You Should Know for 2018

When you’re signed up for AP U.S. History, you know that you’re going to stay busy throughout the year. You have books to read, dates to remember, themes to explore, and tests to study for. To remember everything that you need to know, get a planner. Then, write down the following important APUSH test dates. February If you would like to request accommodations for the exam, you need to submit the request it in February. Some of the accommodations available include: Extended testing time Larger print Larger block answer sheets Use of a braille translator Assigned reader or writer Written copy of oral instructions If you miss the deadline to apply for the needed accommodations, you won’t be able to receive the accommodation that you require. Or, the exam score won’t count. Submit your request early in February to be sure that you will receive the accommodation by test time. March 15th If you are homeschooled or attend a school that doesn’t offer the AP U.S. History course, you need to contact AP services to find an approved AP coordinator. The AP coordinator will find a location for you to take the exam and set up everything for test day. Plan on reaching out to AP services as early as March 1st. But, don’t miss the deadline of March 15th to be sure that you can take the exam on testing day. May 11th The AP exams are administered during the first two weeks of May. The APUSH test days are typically on the first Friday of May. For example, in 2018, the test day is Friday, May 11, 2018. APUSH is usually administered during the morning session. July You’ve taken the exam. Now, the waiting begins. What was your score? Did you pass? You’ll find out in July. This is the time when scores are sent out to students and their high school and colleges of choice. If you need to alter which colleges receive your scores, contact AP Services by the middle of June. Send a written request with the list of colleges that you would like to receive your test scores. Which APUSH test dates apply to you? Make sure that you’re aware of the important dates, and jot them in your planner or on your calendar. Then, get to work. Create your study plan to ace the exam and get the scores that you want.

Interview Questions for Private School Admissions

The private school interview is an important part of the application process. In a typical interview for fifth grade and above, the student applicant meets one-on-one with a member of the admissions staff to discuss the students interests and experiences. The interview adds a personal dimension to the application and helps the admissions staff assess whether the student will be a good fit for the school. Weve outlined below some additional common questions that interviewers at private schools may ask and some potential ways to think about answering the questions. What is your favorite/least favorite subject and why? It may be easier to start with the subject you like the best, and there is no right answer to this question. Just be authentic. If you don’t like math and adore art, your transcript and extracurricular activities probably reflect this interest, so be sure to speak genuinely about the subjects you like, and try to explain why you like them. For example, you might say something along the lines of: â€Å"Art gives me the opportunity to build things with my hands, which I enjoy.†Ã¢â‚¬Å"I like solving problems in math.†Ã¢â‚¬Å"I have always been interested in American history since I grew up in a historic town.† In answering the question about what you like least, you can be honest, but avoid being overly negative. For example, don’t mention specific teachers you don’t like, as it’s the job of a student to learn from all teachers. In addition, avoid statements that express your dislike of work. Instead, you can say something along the lines of: â€Å"I have struggled with math in the past, because ... History hasnt been the easiest subject for me, but I’m meeting with my teacher and trying to work on it.† In other words, show that you are working hard in all your subject areas, even if they don’t come naturally to you. Who are the people you most admire? This question is asking you about your interests and values, and, again, there is no one right answer. It’s worthwhile to think about this question a bit in advance. Your answer should be consistent with your interests. For example, if you love English, you can speak about the writers you admire. You can also speak about teachers or members of your family you admire, and explain why you admire these people. For example, you can say something along the lines of: â€Å"I admire my grandfather, who came from Hong Kong and ran his own business in a new country.†I admire my dad because he is hard-working but still makes time for me.I admire my coach because she pushes us, but also explains why we need to do certain things. Teachers are an important part of private school life, and generally, students in private schools get to know their teachers quite well. You may want to speak about what you most admire in some of your current or previous teachers and reflect a bit about what you think makes a good teacher. That kind of thinking reflects maturity in a potential student. What questions do you have about our school? The interviewer may conclude the interview with an opportunity for you to ask questions, and it’s important to think about some potential questions in advance. Try to avoid generic questions such as, â€Å"What extracurricular activities do you offer?† Instead, ask questions that show you know the school well and have done your research. Think about what you can add to the school community and how the school can advance and develop your interests. For example, if you are interested in community service, you can ask about the school’s opportunities in this area. The best school for any student is the school that’s the best fit, so while you are researching the school, you can determine whether the school is a place where you will grow. The interview is another opportunity for you to find out more about the school—and for them to find out who you are. That’s why it’s best to be genuine and honest, so you can wind up at a school that†™s right for you.

Things Fall Apart By Chinua Achebe - 2333 Words

The President of the United States, Barack Obama, once said â€Å"The worst thing that colonialism did was to cloud our view of our past.† The thoughts that President Obama was trying to portray is the loss of true customs and values that many humans were deprived of when imperialism was in placed. Colonialism brought upon so much of a change, that it is impossible to see true heritage in its original form. In the novel Things Fall Apart, this change is very well seen. Written by Chinua Achebe whom was first born in Nigeria in 1930 to parents who believe strongly in Christianity, who belief were changed after their nation was colonized. Fortunately, he was able to experience the customs of his native people from ages ago with the help of his grandparents who firmly did not believe in colonialism and what they had to offer. When the renowned novel, Things Fall Apart, was written, it was written in response to thoughts of Europeans who previously wrote on point of views of Afric a and Africans (Chinua Achebe Bio). This novel in particular is centered on the life of Okonkwo. Okonkwo was known for having several wives, having a successful harvest, and his victory against one of the strongest wrestlers in the village. As the novel continues, Okonkwo is exile from his village because of an accidental death of a man. While he is gone, white missionaries arrive in his village of Umuofia and attempts to colonize the village (Achebe). In retrospect, such cultures in Nigeria, had a richShow MoreRelatedThings Fall Apart By Chinua Achebe1415 Words   |  6 Pagesbook Things Fall Apart by Chinua Achebe does just that. This book should be taught in schools because it shows the values and traditions of Achebe’s Igbo culture, persistently teaches life lessons throughout the book, and shows the darker reality of European colonialism in Africa. Chinua Achebe is known as one of the most influential and famous authors to ever write. Chinua Achebe originates from an Igbo background and he expresses that through his writings very well including Things Fall ApartRead MoreThings Fall Apart by Chinua Achebe1324 Words   |  6 Pages Chinua Achebe chose to write his novels in English to reveal a deep response of his people to colonisation and to make that response understood to people all over the world. Things Fall Apart was written in English to teach people worldwide of the struggles he faced and the people of Nigeria faced growing up. Many authors and critics have written about Achebe’s ‘Things fall apart’ adding their valued opinion on what he was trying to say and his decision to write in English. In the followingRead MoreThings Fall Apart By Chinua Achebe Essay1203 Words   |  5 Pages who took their land for monetary gain. This was a dark period of time for Africans that live there. The U.S. Civil War and The Great Depression both can be related, in this instance, to how down their people were because of what happened. Chinua Achebe said it best, â€Å"I would be quite satisfied if my novels...did no more than teach my readers of their past...was not a long night of savagery from which the first European acting on God’s behalf delivered them†(qtd. in â€Å"Morning Yet† 45). In theRead MoreThings Fall Apart By Chinua Achebe1452 Words   |  6 Pagesassume control over the Roman Empire. However, imperialism in Africa remained a recorded element from 1750 to 1945. This paper visits how control and changes were influences over the Africans during this time period as seen through Chinua Achebe’s novel Things Fall Apart. (UKEssays, 2015) Europe was experiencing a few financial and political changes that forced the major European forces to investigate abroad regions to add to their resources during the seventeenth century. In order for the EuropeanRead MoreThings Fall Apart By Chinua Achebe2361 Words   |  10 PagesThings Fall Apart Book Critique Things Fall Apart by Chinua Achebe is a historical fiction novel describing the life of Okonkwo in a Nigerian village succumbing to European ways, in order to portray Achebe’s view on imperialism. It was chosen for us to read by our teacher because it describes imperialism and its effects in an Ibo village of Nigeria. It also shows the treatment of natives by the Europeans and how the natives reacted. Things Fall Apart is useful to our course of studies because itRead MoreThings Fall Apart By Chinua Achebe1265 Words   |  6 PagesThings Fall Apart by Chinua Achebe is markedly relevant to our current course of studies in World History, as it tells a story based on European Imperialism in Africa. Coming off the heels of our Imperialism unit, this post-colonial novel provides very helpful context on different civilizations’ perspectives throughout the Age of Imperialism; aside from analyzing death tolls, descriptions of conflicts, and names of countries, it was previousl y hard to envision what life was actually like during thatRead MoreThings Fall Apart by Chinua Achebe 735 Words   |  3 PagesThings fall apart. Achebe. Ernest Gaines once said, â€Å"I write to try to find out who I am. One of my main themes is manliness. I think Im trying to figure out what manliness really is.† Indeed, every society or culture has its own understanding of an ideal man. Even though these characteristics are different in various parts of the world, the significance of masculinity can never be overestimated. â€Å"Things Fall Apart† by Chinua Achebe is considered as one of the best examples of a riseRead MoreThings Fall Apart by Chinua Achebe692 Words   |  3 Pagesthe way to go. Through commercial trading Islam spread into Igboland, and this led to more Igbo people leaving the Igbo way of life for another, whether it be Islam or Christianity which divide the country in two. In the novel Things Fall Apart written by Chinua Achebe British colonialism and the migration of Muslims to Nigeria led to the change in the faith, social and economic changes in the Igbo society. Traditional Igbo faith believes that there is only one creator or god known as ChinekeRead MoreThings Fall Apart By Chinua Achebe897 Words   |  4 PagesIn the novel, â€Å"Things Fall Apart† by Chinua Achebe the Igbo tradition revolves around structured gender role. Everything essential of Igbo life is based on their gender, which throughout the novel it shows the role of women and the position they hold, from their role in the family household, also planting women crops, to bearing children. Although the women were claimed to be weaker and seemed to be treated as objects, in the Igbo culture the women still provided qualities that make them worthyRead MoreThings Fall Apart By Chinua Achebe Essay1851 Words   |  8 Pageschoice and styles are critical not only to the reader’s understanding of the text but to his appreciation as well. How language is effectively manipulated in their writings enhances the reader’s valuing of the works. The selected novel Things Fall Apart by Chinua Achebe is a representation of Igbo culture and their language. It explores the life of an Igbo tribe at the time of when colonization hit Africa. It could be considered as a post-colonial text, as the protagonist of the story and the other

Life Cycle Assessment in Built Environment - Myassignmenthelp.Com

Questions: 1. As an accountant of the company, you would like to have a better understanding of how the sustainability of the company will impact on the stakeholders. You believe the most efficient way is to identify important stakeholders. Refer to the case and identify five relevant stakeholder groups and discuss how different accounts could be used to satisfy each groups information requirements.2. In order to enhance companys performance, the CEO thinks it might be insufficient to use profit as the only performance indicator, and is considering using a range of key performance indicators to manage the business. You believe the Balanced Scorecard is a useful performance measure framework that can be used, as it gives management an overall picture of companys performance. You have been asked to develop a Balanced Scorecard to assist RTXM in managing its overall companys performance and demonstrate how it works to the management and staff in next company meeting. You need consider ONE of the m ost important metrics that could be used for each of the four perspectives of performance and explain the reason why it has been selected and how it can be used to improve companys performance.3. The CEO believes the company was attractive because of its previous low price strategy but has also noticed unprecedented awareness from customers on the companys social responsibilities. The CEO approaches you to discuss the selection of supplier, which supplier is better for companys strategic development. Provide an explanation to the CEO with reference to the potential costs and benefits of working with both Super Cheap and Green Fashion.4. After your analysis above, the CEO starts realizing the importance of working with social and environmental friendly suppliers, however, still does not have a comprehensive understanding to the positive and negative impact his companys products might have both socially and environmentally. You decide to use the Life Cycle Analysis (LCA) for a product that the company offers to enhance their understanding. Draw the LCA, and select one or two stages of the LCA, identifying a total of four possible social and environment impacts. If the impact is detrimental either socially or environmentally, give suggestions to minimize the impact. If the impact is positive, give suggestions as to maximize the benefit. You are required to undertake some research to answer this question.5. Subsequently the company decides to contract with the Green Fashion. Some important shareholders attempted to block this proposal. Their belief, as the owners of this company, is that the company should aim to maximize the value of their shares, however, the new business plan could significantly increase the costs and therefore reduce the profit. You are required to identify an organisation, business or industry and explain whether and how it could potentially increase the value of its shares in the long term by being accountable to its major stakeholders. You are required to undertake some research to answer this question. Answers: Answer 1 The five key stakeholders along with the relevant accounts for satisfying the informational needs are highlighted below (Deegan, 2014). Shareholders The decision regarding supplier can impact the profitability of the company and hence the net worth. As a result, the existing 20 shareholders of the company are stakeholders. The key accounts of importance for the shareholders would be the net profit to begin with but would include metrics related to injuries to workforce (including those of suppliers). Customers Sustainability has become increasingly important for customers who desire to buy goods from manufacturers having ethical practices. As a result, the sourcing decision could impact the preferences of customers making them stakeholders. The sourcing policy along with the metrics related to environment sustainability and consumer complaints refunds are essential. Also, the sales account in terms of price charges would be critical. Government/Professional Bodies Ethical sourcing has become significant ever since the abysmal labour practices followed in the sweat shops have come to light. As a result, there have been agreements in the clothing industry whereby the big brands have taken measures to focus on ethical sourcing. Key account closely watched would relate to the sustainability report, the sourcing policy, employee related injuries along with performance metrics. Suppliers The sourcing policy adhered by the company has a impact on the present as well as potential suppliers in the future. The informational needs can be fulfilled from the sustainability report besides the balance sheet which would indicate the financial strength of the company. Lenders The sustainability practices adopted by the company could impact the lenders owing to potential financial impact of any lapse. In case of sourcing from Bangladesh, there is considerable risk to the business which could increase credit risk. Key accounts would be the sourcing policy, sales, profits along with liquidity indicators (both short term and long term). Answer 2 Balanced scorecard is a tool to ensure that the performance metric of the business are broad based and hence not too much biased towards economic performance. Considering that the balanced scorecard enables the business to focus on other critical aspects such as learning and customer satisfaction, hence this leads to higher sustainability for the business. There are essentially four perspectives namely financial, customer, internal business processes along with learning and growth. The most critical metric for each of these performance dimensions has been outlined below (Adams, Neely and Kennerley, 2007). Financial The two key important metrics would be sales growth along with profit margin. However, the more significant of the two metrics would be profit margins especially considering that the company would go with expensive but green supplier. As a result, the margins in short term could be under pressure and as a result series of cost cutting measures may be initiated by the company whose effectiveness would be captured by this metric. Customer The number of customers complaints received as a percentage of transactions should be the appropriate metric. This becomes significant in the wake of increasing complaints from the customer that the business faces in wake of expansion. Keeping customer complaints under check would enhance the customer satisfaction. Internal business processes The product quality is a critical metric in this regard. The company should aim to bring the damaged or defective goods to less than 0.5% of the total goods manufactured. This would lower the costs related to repair, replacement and quality check and would enhance the overall customer satisfaction along with profitability. Learning and growth The company should aim to improve the online shopping experience as it an area of weakness and has tremendous scope for growth. Also, this would help the business lower down costs and improve operational profitability. A suitable metric could be clicks generated along with conversion rate of clicks. Answer 3 In order to choose between the two suppliers, a cost benefit analysis needs to be performed as indicated below. Supplier 1: Super Cheap Benefits: It would provide a vast array of products desired by the business at very cheap prices in limited time which would help the company enhance the market share and the profitability of business. Higher profitability in turn would lead to creation of wealth for shareholders Costs: Owing to poor past record with regards to sustainability and labour practices, negative publicity can be generated for the company especially in case of any unfortunate incident. This is especially likely in an environment where customers are quite sensitive about social responsibilities of business. The company could potentially invite lawsuits for unethical sourcing involving practices such as child labour which besides financial costs could adversely impact the expanding business. Green Fashions Benefits: The company boasts of ethical practices which the company can promote amongst the customers and hence look to charge premium from the customers. No risk to the reputation in the long run Matching value system and sustainability goals make the relationship sustainable Costs: The associated costs of the products would be higher forcing the company to alter business model and look at other ways to bring down operational costs. Conclusion The preferred choice would be Green Fashions even though in the short run, the company may have to alter the business model to accommodate the higher costs. However, in the long run, the company does not face high risk of reputation and customer loss on account of unethical sourcing. Besides, the common values make the business relationship more sustainable. Answer 4 The various stages of the LCA are highlighted below (Finnveden et. al., 2009). The two stages which have been chosen for this analysis are inventory analysis and impact assessment. In inventory analysis, the focus is on the inputs and the outputs generated. The impact assessment focuses on the effect related to the use of resource and related emissions and classifying the same in different categories of impact (Crawford, 2011). The product can be chosen as a T-shirt. The various social and environment impacts are outlined below (Finnveden et. al., 2009). In case of unethical sourcing (i.e. by choosing suppliers such as Super Cheap), the environment would be damages severely owing to the discharge of the untreated waste directly into rivers. In order to mitigate the same, the company should choose a supplier which minimises waste generation or disposes the same in a responsible manner. Further, pollution of the river could have severe environmental consequences to the marine life which is apparent from Super Cheap practices. In order to mitigate this, it becomes necessary that supplier should comply with environmental norms and ensure that the marine life is not adversely impacted. There are adverse social consequences with regards to various settlements near the polluted water bodies owing to the manufacturing of T-shirts. As a result, they might be required to migrate to another place where drinking water is available. In order to reduce this undesirable effect, the dumping of waste and pollutants in rivers should not be practiced and only such suppliers should be entertained. Further, it is quite possible that these t shirts are produced using child labourers who are employed in sweat shops. This leads to their exploitation and hampers their education growth. For mitigation, it is imperative that a supplier should be chosen that does not use child labour so that this social menace can be discouraged. Answer 5 The clothing industry in the west (whether be it US or UK) is an example of industry which can improve and act in the interest of the majority shareholders so as to create wealth for them in the long run. A key practice which is followed by major players in this industry is outsourcing their cloth manufacturing to South East Asian countries which happen to be major textile manufacturers. One of the key reasons for this outsourcing is the lure of lower costs owing to availability of cheap labour. However, the sub-contractors and contractors in these countries in a bid to further lower costs tend to deploy a sizable amount of child labour. It is estimated by the ILO (International Labour Organisation) that about 170 million children across Asia work as child labour with a predominant share being concentrated in the garment industry (Moulds, 2016). Considering the complexity of the global supply chains, at times the big brands are not aware of such practices at the site of contractor. However, there have been instances in the past when despite being aware of such practices, no concrete action has been taken in order to safeguard their own interest of maximising profitability. However, this goal is not achieved as has been seen from the experience of Nike and Adidas which have faced tremendous implications for running sweat shops for manufacturing of shoes. It is essential that the clothing industry takes a clue from their experience and understand that in the long run, wealth can be generated for the majority shareholders only through sustainable and ethical business practices (Hymann, 2017). Going forward, it is expected that this practice would tend to diminish which would auger well for the cloth industry in the west despite some hiccups on the cost side. References Adams, C.; Neely A. and Kennerley M. (2007)Performance measurement frameworks: a review, 3rd ed., Cambridge: Cambridge University Press Crawford, R.H. (2011) Life Cycle Assessment in the Built Environment, 2nd ed., London: Taylor and Francis. Finnveden, G., Hauschild, M.Z., Ekvall, T., Guine, J., Heijungs, R., Hellweq, S., Koehler, A., Pennington, D. and Suh, S. (2009) Recent developments in Life Cycle Assessment, Journal of Environmental Management, 91(1),pp. 1-21 Hymann, Y. (2017) Child Labour in the fashion industry, [Online] Available from: https://goodonyou.eco/child-labour/ [Assessed March 9, 2018] Moulds, J. (2016) Child Labour in the fashion supply chain, [Online] Available from: https://labs.theguardian.com/unicef-child-labour/ [Assessed March 9, 2018]